Prior to entering into comedy, Hooper worked in children's and adult theatre in Perth, Western Australia, as an actress and director.

In 2006, Hooper performed a one-hour live show titled Oh inspired by the incident, during which she did not speak at all, instead communicating through recorded audio, videos, handwritten signs, breakdancing and mime.

Her television credits include guest stand-up appearances on Stand Up Australia and Rove Live, a presenting role on How the Quest Was Won and a regular segment on The Sideshow.

She was a member of the negating team with Stephen K. Amos and Greg Fleet in the 2007 Melbourne International Comedy Festival's Great Debate which aired on Network Ten.

In July 2015, Hooper and Mel Buttle were announced as the hosts of the second season of The Great Australian Bake Off, which began airing on LifeStyle Food in October 2015.