She appeared several in films including Black is White (1920) directed by Charles Giblyn and played the leading role in a touring production of Polyanna in 1919.

[3] Mersereau's final film credit came as Lyda Desmond in Black is White (1920), directed by Charles Giblyn and starring Holmes Herbert, Jack Crosby, Clifford Bruce, and Lillian Lawrence.

[2] In 1919, she played the leading role of Pollyanna Whittier in a touring production of Polyanna, which was adapted for the stage by Catherine Chisholm Cushing from the novel series of the same name by Eleanor H.

[5] Her performance was generally praised by critics, with the Green Bay Press-Gazette writing that "The little star is just a bundle of gladness on the stage and her rare bits of humor frequently brought forth much applause.

[7] On Broadway, Mersereau originated the roles of Countess Ermintrude in Forbidden (1919-1920), Vivienne in Sophie (1920) and Lydia Bertram in George M. Cohan's American Born (1925).