Claire A. Pierangelo is an American diplomat who serves as the United States ambassador to Madagascar and the Comoros.

Pierangelo earned a Bachelor of Arts from the University of California, Santa Cruz, Master of Science in National Security and Resource Strategy from the Dwight D. Eisenhower School for National Security and Resource Strategy of the National Defense University, and a Master of Arts from the Paul H. Nitze School of Advanced International Studies of Johns Hopkins University.

A career member of the Senior Foreign Service, Pierangelo served as the deputy chief of mission of the U.S. Embassy in Hanoi, Vietnam (from 2011 to 2015)[1] in addition to other positions, including multiple assignments in the Bureau of European and Eurasian Affairs in the U.S. State Department and service as principal officer at the U.S. Consulate General, Surabaya, Indonesia.

On June 24, 2021, President Joe Biden nominated Pierangelo to be the next United States Ambassador to Madagascar and Comoros.

[7] She speaks Italian, Indonesian, Vietnamese, French, Haitian Creole, and some Spanish.