When trains leave this depot, they connect with the Midland, Fremantle, Armadale, Thornlie, and Yanchep lines.

[4] The railway depot's primary purpose is to service, refurbish and upgrade Transperth's A-Series railcars.

The newer B-series railcars may also be stabled at Claisebrook railway depot for work that cannot be done at Mandurah or Nowergup at any time and for events such as the Australian Football League games on weekends at Perth Stadium and also for the Airport trains on the Airport Line.

The depot has also recently started serving as the facility to maintain and refurbish the diesel-electric Transwa Australind railcars.

The Claisebrook railway depot has facilities to store, maintain and clean the fleet of railcars.