[5] After leaving Holy Cross School,[6] she went on to study media arts with professional and creative writing at St Mary's University College.

[8] Amfo hosted the British premiere of Red Riding Hood, Baby Driver, Tomb Raider, Kingsman and Marvel's Black Panther at Hammersmith Apollo and has reported from events in the UK, including Wireless, Global Gathering, SW4 and NASS festivals.

In June 2020, Amfo was widely praised for making a speech on her mid-morning show on BBC Radio 1, about George Floyd's murder, racism and its effect on her own mental health.

[18] Amfo began presenting the Future Sounds show on Radio 1 from 30 July 2021, taking over from Annie Mac, who left the station.

In February 2022, she was a guest judge on the Snatch Game episode for the first series of RuPaul's Drag Race: UK vs. the World.

[22] In December 2023, Amfo and Raye appeared on the twelfth series of The Voice UK as guest mentors for team Anne-Marie.