Clarice di Piero de' Medici (1489–1528)[1] was the daughter of Piero di Lorenzo de' Medici and Alfonsina Orsini.

Born in Florence, she was the granddaughter of Lorenzo de' Medici, niece of Pope Leo X and sister to Lorenzo II de' Medici.

After her brother's premature death in 1519, she educated his daughter Catherine, the future Queen of France.

In 1508 she married Filippo Strozzi the Younger and moved to Rome.

She died in 1528 from either miscarriage or childbirth complications of a stillborn child