Claude de Lorraine, Duke of Guise (20 October 1496 – 12 April 1550) was a French aristocrat and general.

Claude was born at the Château de Condé-sur-Moselle, the second son of René II, Duke of Lorraine, and Philippa of Guelders.

On 9 June 1513, at the age of sixteen, Claude married Antoinette de Bourbon (1493–1583),[1] daughter of François, Count of Vendôme.

In 1521, he fought at Fuenterrabia, and Louise of Savoy ascribed the capture of the place to his efforts.

In 1523, he became governor of Champagne and Burgundy, after defeating at Neufchâteau the imperial troops who had invaded this province.