Clayton is a city in Decatur and Norton counties in the U.S. state of Kansas.

[6] According to the United States Census Bureau, the city has a total area of 0.43 square miles (1.11 km2), all land.

[7] The 2020 United States census counted 44 people, 22 households, and 14 families in Clayton.

27.3% of households consisted of individuals and 13.6% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 96.6% White and 3.4% Native American.

25.9% of all households were made up of individuals, and 3.7% had someone living alone who was 65 years of age or older.

There were 13.3% of families and 10.3% of the population living below the poverty line, including no under eighteens and none of those over 64.

Clayton and rural areas east of the community are served by Norton USD 211 public school district.

[18] Northwest rural areas (north of highway 383) are served by Oberlin USD 294.

Southwest rural areas (south of highway 383) are served by Hoxie USD 412.