Clayton Milborne (born after 1676 – 1726), of Bloomsbury Square; St. Giles-in-the-Fields, Middlesex and Judde House, Ospringe, Kent, was an English Tory politician who sat in the House of Commons from 1708 to 1715.
He was returned unopposed as Tory Member of Parliament (MP) for Monmouth Boroughs at the 1708 British general election with the backing of the Duke of Beaufort.
He voted against the impeachment of Henry Sacheverell in 1710 and was returned unopposed again at the 1710 British general election.
He voted with the Court in support of the French commerce bill on 18 June 1713.
He died at his home in Kent on 13 September 1726, and was buried at the parish church of St Luke, Chelsea, near his father .