Giacomo della Porta was commissioned to erect a suitable building to house them, which would be one of the aged architect's last projects.

On February 25, 1601, Urban VIII[disputed – discuss] shifted the Slavs to Loreto and refounded the Collegio Clementino as an elite school for young noblemen of every nation and the richest families in Rome.

The musical tradition of the Collegio Clementino remained strong: Alessandro Scarlatti wrote oratorios for Carnival seasons and came up from Naples to oversee their production.

In the 17th and 18th century the Collegio Clementino produced Pope Benedict XIV, and numerous cardinals, including Domenico Silvio Passionei,[2] Francesco Guidobono Cavalchini,[3] Bartolomeo Pacca,[4] Fabrizio Sceberras Testaferrata,[5] the mathematician Giulio Carlo de' Toschi di Fagnano, and the Pacific explorer Alessandro Malaspina.

[6] Here Carlo Spinola and Domenico Quarteironi taught the young polymath and inventor, Raimondo di Sangro, prince of Sansevero.