The Clemson Tigers field twenty-one athletic teams, nine men's and twelve women's, across thirteen sports.

Clemson's fight song is a rendition of the Original Dixieland Jazz Band's Tiger Rag.

It was created by John Antonio and developed by Helen Weaver of Henderson Advertising in Greenville, South Carolina, from a mold of a Bengal tiger sent to the agency by the Field Museum of Natural History in Chicago.

Much of the baseball program's success occurred under Bill Wilhelm during his 35 seasons as Clemson's head coach.

Erik Bakich is the Tigers' current head coach, having replaced Monte Lee after the conclusion of the 2022 season.

The 1981 squad, led by Head Coach Danny Ford, became the first athletic team in school history to win a national championship.

Clemson defeated Nebraska 22–15 in the Orange Bowl in Miami, Florida, to win the 1981 NCAA Football National Championship.

After Tommy Bowden resigned midseason on October 13, 2008, Dabo Swinney took over as interim head coach.

[14] Before each home game, the team ends pre-game warm ups and proceeds to the locker room.

With five minutes to go before game time, three buses leave the street behind the West Endzone carrying the Clemson football players.

The buses pull to a stop at the gate in front of The Hill, and the Tigers gather at the top, where each player proceeds to rub "Howard's Rock", which is an imported rock from Death Valley, California that was presented to Frank Howard in 1967.

[16] In addition to that victory, Clemson also won the ACC and NCAA East Regional titles that year, making the Tigers the first program in NCAA history to win its conference, regional, and national championship tournaments in the same year.

[12] Their gymnastics team made their competitive debut on January 12, 2024, winning their inaugural meet against William & Mary.

That year, Kelly Murphy, Lydia Hassell, Callen Erdeky, Allison Colberg, and Meredith Razzolini, won the NCAA title in Fours.

Famous former Tigers include Oguchi Onyewu, Stuart Holden and Paul Stalteri, all three whom are capped for their respective nations, and Hermann Trophy winners Bruce Murray (1987), Wojtek Krakowiak (1998), and Robbie Robinson (2019).

The women's soccer team has won the ACC regular season crown twice, and advanced to the NCAA tournament twenty-four times.

[26] Jay Berger was a two-time All-American for Clemson, and went on to a pro career in which his highest world ranking was #7.

The men's team won the ACC championship in 1979, and participated in the NCAA tournament every year from 1976 through 1982, when they finished as runners-up.

The wrestling program began in 1975 winning the ACC title as a team under coach Eddie Griffin in 1991.

[34] Noel Loban won Clemson's first national title in 1980, and went on to win a bronze medal in the 1984 Olympics.

Clemson has a lesser rivalry with the University of Georgia, born because of the two institutions' close proximity (roughly 75 miles apart).

The men's and women's basketball teams play at Littlejohn Coliseum, which has a listed capacity of 10,000 spectators.

Littlejohn also acts as a venue for a variety of campus functions throughout the year, including concerts and graduation ceremonies.

Recently renovated Doug Kingsmore Stadium is home to Clemson's men's baseball team.

The men's and women's soccer teams play their home games at historic Riggs Field.

Other home venues for these sports are: Walker Golf Course, Hoke Sloan Tennis Center, Jervey Gym (volleyball), Rock Norman Track Complex, and McHugh Natatorium.

[71] Clemson again finished the spring 2013 season with a 6-1 conference record, and then defeated South Carolina 29–7 in the round of 16 national playoffs, before losing in the quarterfinals to Central Florida 20–24.