He threw and batted left-handed, stood 6 feet 3 inches (1.91 m) tall and weighed 208 pounds (94 kg).

[1] He broke into the major leagues with the Chicago Cubs in 1948, and he was pleasantly surprised to find out that he had been traded to the Pittsburgh Pirates before the 1949 season.

[2] Before the 1950 season, Chambers had threatened not to sign with Pittsburgh unless he made $20,000, a large increase from his $7,500 salary the year before.

[4] A month later, on June 15, the Pirates traded Chambers and Wally Westlake to the Cardinals for Dick Cole, Joe Garagiola, Bill Howerton, Howie Pollet and Ted Wilks.

Over his six MLB seasons, Chambers compiled a 48–53 career won–lost record with an earned run average of 4.29, with 37 complete games and seven shutouts in 113 starts.