[6] The executive producers of the show include Jennifer Oxley, best known for co-creating Peg + Cat, and Vince Commisso of 9 Story Media Group.

Jetta, Vaz, Charlie, T-Bone, Mac, and Cleo are all removed from the reboot, with Samantha, Jack, Pablo, Tucker and Bailey replacing all the classic characters.

[11] Scholastic and 100 Chickens Productions in the United States, and 9 Story Media Group in Canada produce the series.

Emily and Clifford help out using methods inspired by what they read in a cowboy book, and attempt to find a home for the grey kitten that's the most playful of them.

"Knights of the Wobbly Table": Emily Elizabeth and Clifford go to the library to check out an adventure story they had previously read, but learn from Miss Clayton that they haven't returned the book.

"Things That Go Bump": Inspired by a book about camping, Emily Elizabeth and Clifford have a backyard campout with their friends (kids and dogs alike), but although no ghost stories are read by anybody of the group, something seems to be making spooky things happen around the campsite and Emily Elizabeth and Clifford have to be brave to save Sam's new hermit crab Shelley and expose the "ghost".

": After Pablo shares the latest issue of his favorite comic book with his friends, he is over the moon when Mr. Howard tells them that the author is visiting.

"Muddy Buds Hit the Suds": Emily Elizabeth, Clifford, Sam, and Bailey are excited to be playing "race cars" in the mud after a rainfall, but Tucker isn't keen on getting dirty as that means he would have to take a bath afterwards.

"Up Pup and Away": Emily Elizabeth has a surprise for Aunt Violet: paper airplanes with drawings of cherished moments they shared!

"The Birdwell Island Blues": Emily Elizabeth's day has started out terribly and she is in a bad mood!

": Emily Elizabeth and friend are inspired to form a team of superheroes after noticing Fire Chief Franklin rescuing Fisherman Charlie.

When a big emergency strikes, he and his merry band of rescuers arrive to mend all problems of Birdwell Island.

In May 2023, the Governor of Oklahoma, Kevin Stitt, vetoed a measure to provide state funding to Oklahoma Educational Television Authority for three years, due to their broadcasting of Clifford (and of Work It Out Wombats!, which also features same-sex parents) and the claims that it is "overly sexualizing" kids.

The first seven episodes of Clifford the Big Red Dog were released on Amazon Prime Video on December 6, 2019, while PBS Kids began airing the series the next day.