The American program's main curricular goals are centered around children's bedtime routines, of which each episode demonstrates a different aspect.

[2] The program focuses primarily on long-form, in-depth celebrity interviews, designed to help younger viewers connect with others on a deeper level.

[8] Each broadcast included one 15-minute episode of the show, followed by PBS Kids short series, such as City Island and Jelly, Ben & Pogo, to fill the remaining time of the half-hour timeslot.

Sesame Workshop announced the production of an Israeli adaptation of the series, titled The Talk Show with Elmo (תוכנית האירוח של אלמו), which is slated to premiere on Hop!

[9] The pilot show was directed by Benjamin Lehmann and was produced in January 2019,[16][17] and features special guest Kacey Musgraves performing "Rubber Duckie".

[19] In addition to Musgraves, confirmed guests were Jimmy Fallon, the Jonas Brothers, John Oliver, an uncredited actor Victor Joel Ortiz portraying Batman, Jason Sudeikis, Kwame Alexander, Sara Bareilles, Miles Brown, Ciara, Andy Cohen, Dan + Shay, Josh Groban, Mykal-Michelle Harris, H.E.R., Hoda Kotb, Lil Nas X, Blake Lively, John Mulaney, Pentatonix, Ben Platt, Jonathan Van Ness, Olivia Wilde and Sofia Carson.