Clifford the Big Red Dog is a 2021 live-action animated urban fantasy comedy film directed by Walt Becker from a screenplay by Blaise Hemingway and the writing team of Jay Scherick and David Ronn, and a story by Justin Malen and Ellen Rapoport, based on the children's book series by Norman Bridwell.

The film stars Jack Whitehall, Darby Camp, Tony Hale, Sienna Guillory, David Alan Grier, Russell Wong, Izaac Wang, Kenan Thompson and John Cleese.

It was initially scheduled to premiere at the 2021 Toronto International Film Festival in September 2021, to be followed by a theatrical release in the United States on September 17 after being delayed due to the COVID-19 pandemic by Paramount Pictures, but was ultimately pulled from the festival and had its release date removed from Paramount's schedule due to the spread of the SARS-CoV-2 Delta variant.

Mr. Bridwell, who runs an animal rescue tent at a park, introduces Emily to a small red puppy whose family had been taken by dogcatchers.

They try taking Clifford to a veterinarian, but he chases and plays with a man in an inflatable bubble, and he ends up destroying the weight scale.

After learning from the vet's secretary of Bridwell's past miracles with animals and their owners, the Howards plan to get information on his whereabouts.

Wanting to discover the secret of the dog's stature, Zac contacts the police, falsely claiming to have genetically engineered Clifford, and leads a citywide manhunt for him.

Emily and Casey are evicted from their apartment by Packard (who Zac also tipped off) and pursued by the cops and Lyfegro henchmen after the former refuses the businessman's bribe.

The three shelter in Owen's lavish apartment, where Casey tells his niece that Clifford can stay with her, provided they find Bridwell and have him shrink the dog down to his original size.

However, Tieran, who arrived right after Emily finished her monologue, orders the police chief to see who Clifford's owner is by scanning an ID chip his scientists secretly implanted earlier.

[17] On September 25, 2017, it was reported that Walt Becker had been hired to direct from a script being re-written by Ellen Rapoport, and from the original written by Justin Malen, which would be produced by Forte through her Silvertongue Films banner.

[21] In June 2019, Cleese, Guillory, Wang, Grier, Rosie Perez, Keith Ewell, Bear Allen-Blaine and Lynn Cohen joined the cast.

[30] Clifford the Big Red Dog was simultaneously released in theaters in Dolby Cinema and streaming on Paramount+ on November 10, 2021, in the United States.

[6] In the United States and Canada, Clifford the Big Red Dog was projected to gross $15–17 million from 3,695 theaters over its first five days.

The website's critics consensus reads: "It may get younger viewers to sit and stay, but Clifford the Big Red Dog is nowhere near as charming as its classic source material.

"[55] Angie Han of The Hollywood Reporter wrote: "It's not reinventing the wheel or breaking new ground; [and] it's unlikely to wow audiences with its bold artistic vision or profound emotional depths.