Clifton is a census-designated place (CDP) and post office in and governed by Mesa County, Colorado, United States.

[7] Clifton is in central Mesa County, bordered to the west by the city of Grand Junction and to the northwest by unincorporated Fruitvale.

Interstate 70 passes along the northern edge of Clifton, with access from Exit 37 (I-70 Business).

Colorado State Highway 141 leads south from US 6, 5 miles (8 km) to U.S. Route 50.

Colorado Mesa University Tech operates a community campus in Clifton, offering technical certificates and non-credit courses open to the public.