It is part of the Grand Junction, CO Metropolitan Statistical Area.

[3] The Grand Junction post office (ZIP Code 81503) serves the area.

[4] Orchard Mesa is in central Mesa County, on the southeast side of the city of Grand Junction, the county seat.

U.S. Route 50 passes through the community, leading northwest into Grand Junction and southeast 37 miles (60 km) to Delta.

The United States Census Bureau initially defined the Orchard Mesa CDP for the 1960 United States census.