Clinton High School was originally housed on Hampton Avenue; it opened in 1917.

This school was later replaced by a new building on North Adair Street, which opened in 1956.

The Red Devils' main rivals are the Laurens Raiders; their annual season-opening rivalry football game attracts some 10,000 spectators each year.

Clinton hosts football games off-campus at Richardson Field at Wilder Stadium[3] (located on campus at the old high school building), as they have since 1975.

The Clinton High School Gymnasium hosts men's and women's basketball, as well as volleyball.