Clodine (/ˈkloʊdiːn/ KLOH-deen) is an unincorporated community in Fort Bend County, Texas, United States.

Clodine was first established in the 1880s as a station on the San Antonio and Aransas Pass Railway.

The Texas and New Orleans Railroad bought the San Antonio and Aransas Pass line in 1934 and removed the depot and section houses.

In 1947, Clodine had a population of fifty and was a shipping point for surrounding farms and a local oil field.

In April 2008, the Clodine General Store was moved to make room for the expansion of Farm to Market Road 1464.