The Sienna subdivision is on land that previously operated as a sugar and cotton plantation.

Purchased in 1840 by South Carolinian Jonathan D. Waters, the tract included a wharf along the Brazos River.

In the mid-1980s the Johnson Corporation began construction of single-family homes, roads, and a 10-mile-long (16 km) levee for flood protection.

The Brazos River runs just west of the western border of Sienna, and Oyster Creek flows southwards through the center of the CDP.

[8] As of the 2020 United States census, there were 20,204 people, 6,089 households, and 5,494 families residing in the CDP.

[33] Sienna Lutheran Academy is a private school that caters to the Christian education of children in grades K-8.

[34] Before 2010 the portion east of Sienna Parkway was zoned to Hightower High School in Missouri City, while the portion west of Sienna Parkway was zoned to Elkins High School in Missouri City.

[44] Fort Bend County Libraries operates the Sienna Branch, which opened on April 24, 2010.

The $15 million, two story facility, which has 45,000 square feet (4,200 m2) of space, was a joint project between the library system and Houston Community College.

[44] The Sienna Branch has a 3D printer for the community to use and offers classes on 3D design and printing.

The community has lakes, parks, trees, and a trail along 4 miles (6.4 km) of the frontage of the Brazos River.

The Sienna sports complex is the home to a variety of youth club sports programs, including, the Sienna Panthers Lacrosse Club which has 240 youth lacrosse players ranging from 1st grade to High School.

It is also the home field for Team 91 Texas which provides elite Lacrosse for 175 players to compete nationally.

The refurbished Club Sienna can now accommodate 85 people in its ballroom and offers a conference room for board meetings and a classroom for up to 25 students.