Clodomiro Picado Twight

In 1915, he published "Anales del Hospital de San José", a quarterly medical publication in Costa Rica.

[3] Dr. Picado was declared "Meritorious of the Motherland" (Spanish: Benemérito de la Patria) by the Costa Rican Congress, by means of decree no.

[4] The scientific work of Dr. Picado was prolific and very extensive; it is calculated that he wrote about 115 research papers in his lifetime, delving into nearly all aspects of his environment: soil, flora, fauna, human tissues, water, and others.

In March 2000, doctors from the San Juan de Dios Hospital in San José, the capital of Costa Rica, published his manuscripts, in which he explains his experiences between 1915 and 1927 with the inhibiting action of fungi of the Penicillium genus in the growth of Staphylococci and Streptococci (bacteria that cause a series of infections).

Although, the discovery of penicillin has been attributed to Alexander Fleming, Picado's old laboratory notebooks from 1923 show records of the antibiosis of Penicillium sp.