In the 2010 season, Fleener had six receptions for 173 yards and three touchdowns in a 40–12 victory over Virginia Tech in the Orange Bowl.

[9] Fleener made his regular season debut in Week 1 against the Chicago Bears, recording six receptions for 82 yards.

[10] He struggled through the early season, before recording his first career touchdown reception against the Detroit Lions in Week 13.

[13] Allen would be placed on injured reserve after Week 1, making Fleener the starter for the rest of the season.

He recorded his first career 100-yard receiving game in Week 11 against the Tennessee Titans, making eight receptions for 107 yards.

[18] In the final game of the regular season, Fleener had two receiving touchdowns in a 27–10 victory over the Tennessee Titans.

[24] Fleener started the 2017 season with consecutive games with a touchdown against the Minnesota Vikings and the New England Patriots.