The Cocklemore Brook is a short tributary of the Bristol Avon, some 2.5 miles (4.0 km) long.

It rises near Studley in Wiltshire, England, and flows in a north and then westerly direction, draining the Pewsham area before passing underneath the former Wilts & Berks Canal and then joining the Bristol Avon near Lackham House, now home to Lackham College.

An alternate name of Pewe Brook is recorded in the 14th century.

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