The hospital has 202 pediatric beds[1] and is affiliated the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.

The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[2][3][4] throughout Long Island and New York state.

[6][7] Cohen Children's Medical Center is the largest provider of pediatric health services in New York state.

[20][19][21] In 2010 child actor, Shannon Tavarez former star of The Lion King died of leukemia at the hospital.

[24][25] In 2017 the hospital gained international attention when they successfully removed a six-pound tumor from 12-year-old Gambian child, Janet Sylvia.

[30][31] As of 2020, Cohen Children's Medical Center has placed nationally in 9 ranked pediatric specialties on U.S. News & World Report.