From 1927 to 1955, it was known as North Country Community Hospital, and at other times it had various names referencing Glen Cove.

[2] It quickly outgrew these facilities, and so its current campus on St. Andrew's Lane was purchased and a new building constructed.

[11][12] In 1971 a new four-story north wing opened, containing a new lobby and emergency room, and facilities for rehabilitation medicine, intensive care, pediatrics, radiology, social services, and admissions.

North Shore University Hospital would merge with Long Island Jewish Medical Center in 1997, and the combined system would be renamed Northwell Health in 2015.

[19] This led to concerns that the hospital would close or be converted to an ambulatory care center, but this did not happen.