During his tenure, he greatly expanded the department's capacity and installed state-of-the-art equipment, and, "In 1991, Lederman became the first doctor in New York to offer brain radiosurgery.

"[6] He also aggressively promoted the new treatment, through media advertisements, interviews, presentations at the hospital, attended by "groups of grateful formal patients" (later dubbed "Lederman clubs" and likened to medicine shows, by trial attorney Jonathan Behrins), and an international tour, comprising Lederman's travels to "Italy, England, Israel, and many other countries to speak to prospective patients and examine their CT scans on the spot.

"[6] In November 2001, Harrison began radiotherapy at Staten Island University Hospital, in New York City, for non-small cell lung cancer that had spread to his brain.

[8][9][6]: 331 [a] The North Campus was constructed in the 1970s when Staten Island Hospital outgrew its original site on Castleton Avenue.

In August, 2021 Northwell announced that they would be renaming the south campus to SIUH Prince's Bay a nod to the community in which the site operates.