The daughter of rapper and media executive Benzino, she began her musical career in 2018 with the release of her debut mixtape, Everythingcoz.

In 2021, the Lil Durk remix of her song "No More Parties" peaked within the top 40 of the Billboard Hot 100 and received double platinum certification by the Recording Industry Association of America (RIAA).

Later that year, her song "Players" peaked within the top ten of the Billboard Hot 100, received platinum certification, and served as lead single for her second studio album, Coi (2023).

[11] In 2011, inspired by her father, she started rapping and released her first songs under the name Coi Leray—"Bow Down", with her brother Taj, and "Rock Back"—via YouTube.

[9] After quitting her job, Leray released her debut single, a response to A Boogie wit da Hoodie's song "DTB" titled "G.A.N.

[1] In December 2018, she was included as a featured artist alongside LouGotCash on the track "Save the Day" by American rapper Ski Mask the Slump God and singer Jacquees from the soundtrack album for the 2018 film Spider-Man: Into the Spider-Verse.

[14] She accompanied American rapper Trippie Redd on his Life's a Trip Tour in early 2019, and released the single "Good Days" in March 2019.

[19] Leray released the single "Big Purr (Prrdd)" in March 2021, featuring vocals from American rapper Pooh Shiesty, which debuted at number 69 on the Billboard Hot 100.

[22][23] Also in April 2021, she made her television debut, performing "No More Parties" on The Tonight Show Starring Jimmy Fallon, and was featured on the remix of Pressa's song "Attachments".

[37] She also appeared on the song "Ocean Prime" from Bfb Da Packman's debut album, Fat Niggas Need Love Too, in June 2021.

Leray's collaborative single with David Guetta and Anne-Marie, "Baby Don't Hurt Me", was released in April 2023.

[52] Leray has cited Missy Elliott, Lady Gaga, Avril Lavigne, Doja Cat, Bon Jovi, Chief Keef, Chris Brown, and Slick Woods as inspirations.