He played college football at North Carolina and was selected by the Washington Redskins in the fifth round of the 2019 NFL draft.

In Week 8 against the Minnesota Vikings, Holcomb forced a fumble on wide receiver Stefon Diggs that was recovered by teammate Ryan Anderson in the 19–9 loss.

[5] In week 12 against the Detroit Lions, Holcomb recorded a team high 13 tackles and sacked Jeff Driskel once in the 19–16 win.

[9] In Week 14, he recorded eight tackles and intercepted Dak Prescott and returned it 31 yards for his first career touchdown in a 27–20 loss to the Cowboys.

[18] He finished the season with 54 total tackles, four for a loss, two quarterback hits, two forced fumbles, and two passes defensed.