Its origins date to 1661, when it was known as Colegio Grande de San Carlos, when the colonial government entrusted the Jesuit Order with the education of the youth.

[2] Nowadays, students from the Colegio Nacional de Buenos Aires rank among the best in most science Olympiads, such as the IPhO, IChO and IBO.

[2] Alumni include many of Argentina's founding fathers, Presidents, members of political parties of all ideologies, internationally recognized scientists, artists, and two Nobel laureates.

A partial list includes: The school offers an astronomy observatory, a swimming pool, a cinema, a sports campus with football, rugby, handball, volleyball, hockey and basketball courts.

Free classes are available such as astronomy, photography, languages, sailing, tango, theater, history of cinema, Yoga, piano, chess, band production and martial arts.