Established in 1822 as one of the UBA's earliest divisions, FMED is presently the largest medical school in Argentina, with over 24,000 enrolled students as of 2011.

Most of the faculty's facilities are housed in a large complex located opposite Plaza Houssay, in the Buenos Aires neighborhood of Recoleta.

Most textbooks and materials used in the department's early years was almost exclusively of French or Italian origin, due to the influence of two renown researchers: Aimé Bonpland and Pedro Carta Molino.

[3] The fall of the regime of Juan Manuel de Rosas revitalized the university, which had suffered budget cuts and persecution at the hands of the caudillo.

For a period of time, the Medical School was separated from the university and depended directly of the Buenos Aires Province government.

A decree issued in October 1852 mandated the creation of the Consejo de Higiene Pública ("Public Hygiene Council"), which re-established the old Academy of Medicine and granted it faculty status.

The Avenida Córdoba building was, eventually, also outgrown, and in March 1939 construction began for a new, larger complex destined to house all of the faculty's facilities.

[4] Despite now housing the Faculty of Economic Sciences, the former FMED site on Avenida Córdoba is still serviced by the Facultad de Medicina station of the Buenos Aires Underground.

[8] In addition, the faculty operates a number of co-dependent research institutes in strategic relation with CONICET, Argentina's national science and technology council.