in the Mind, Brain, Behavior program of the History and Science concentration at Harvard University in 1998.
DeYoung et al.'s (2010)[9] research indicates that the sizes of certain brain regions are related to four of the five different domains of the Five Factor Model.
The volume of the medial orbitofrontal cortex, which is responsible for coding reward values, was positively associated with Extraversion.
Increased volume in the middle frontal gyrus in the left lateral prefrontal cortex, an area responsible for maintaining and executing information and planned action, was positively correlated with Conscientiousness.
Openness/Intellect (Openness to Experience) was the only member of the Big Five lacking a significant relationship to brain structure volume.