[6] The school ceased operations in April 2022,[7] citing challenges faced by private education exacerbated by the COVID-19 pandemic.

The foundation of the College of the Holy Spirit Manila was through a mistaken response to an anonymous letter with a five-dollar bill.

The prelate responded that it was not from him but, pleased with the sisters, he invited them to start a free school for the poor street children of Manila.

[8] During the period, Archbishop Harty was calling religious orders to establish Catholic schools in Manila to preempt the spread of Protestantism in his archdiocese.

663 Legarda Street[9] in Manila to establish the Holy Ghost School on June 17, 1913, as a response to the invitation of the Archbishop.

[10] American Governor-General of the Philippines Francis Burton Harrison through the Division Superintendent of Schools granted Government Recognition and Permit to Operate in 1915.

[11] In 1924, HGC became the Provincial Motherhouse of the SSpS congregation in the Philippines[11] until it was finally moved in Poinsettia Street, New Manila, Quezon City in 1945.

[13] On April 2, 1925, the college department started when it was given government recognition to operate[9] with a two-year course, Associate in Art.

In a letter to the community dated October 28, 2020, Sr. Carmelita Victoria of the SSpS congregation cited K-12 curriculum policies by the government, free tuition in local and state-run institutions, and increased salaries of public school teachers as the challenges being faced with private education, which are further exacerbated by the COVID-19 pandemic.

[20] A portion of the campus, including the gymnasium, has been leased out to National University, which relocated its college of business administration to the CHS site.

In June 2024, the SSpS congregation signed a five-year lease agreement with the National Teachers College for the usage of St. Arnold Janssen building and a portion of the former Social Hall at the ground floor.

A noted deviation from tradition is alumna Felina Co-Young who on June 11, 2011 was appointed by the SSpS Philippines North Provincial Leadership as the first lay woman president of the college.