The College of the Holy Spirit of Tarlac (also referred to by its acronym CHST; colloquially, "Pirit") is a private, Catholic basic and higher education institution run by the Missionary Sisters Servants of the Holy Spirit in Tarlac, Philippines.

[1] CHST has three buildings within Tarlac City—the primary, secondary, senior high school education departments are located in San Sebastian Village.

It was originally an exclusive school for girls but in 2005, they started admitting male students which resulted to its growing population.

In July of the same year, due to its fast growing student population, a new building was constructed at the New Tarlac Heights Subdivision in San Sebastian Village for the College and High School Departments.

He aimed to form a congregation of sisters who will serve as teachers to young girls, and to assist the missions of the priest.