Both governments have maintained a friendly relationship since the 20th century.

The two countries have worked together on different types of projects, including environmental and disaster management, reducing international drug trafficking and organised crime, as well as nutrition and food supply.

[3] During the time of the Viceroyalty of New Granada and Gran Colombia, both countries shared a border, and from there arose the border conflict over the Guayana Esequiba.

[5] In 2018 and 2019, Colombia's foreign ministers (María Ángela Holguín and Carlos Trujillo respectively) travelled to Georgetown and met with members of the Guyanese government.

Five years later in 2022, Colombia also experienced a large trade net with Guyana in the exported products of machines ($13.6M), chemical products ($7.05M), and plastics and rubbers ($6.38M).