Initially, Mexico was accredited to Guyana from its embassy in Port of Spain, Trinidad and Tobago.

In 2014, Mexican Foreign Minister José Antonio Meade paid a visit Guyana during his tour of Caribbean nations.

[6] In October 2015, Guyanese Prime Minister Moses Nagamootoo paid an official visit to Mexico.

[11] Guyana's main exports to Mexico include: aluminum ores and concentrates.

Mexico's main exports to Guyana include: tubes and pipes of iron, steel, household appliances, malt extract and food based products.