The following is the list of number of competitors participating in the Games:[1] Colombia entered one female archer to compete.

[3] Colombia sent one male and one female cyclist after successfully getting a slot in the 2018 UCI Nations Ranking Allocation quota for the Americas.

[4][5][6] Colombia entered a squad of six riders (four men and two women) to compete in their respective Paralympic road races.

[2][7][8] The men's team qualified after winning the bronze medal at the 2019 Parapan American Games held in Lima, Peru.

Angélica Bernal qualified by winning the gold medal at the 2019 Parapan American Games in Lima, Peru.