[5] Following the 1990 U.S. census and associated realignment of Colorado congressional districts, the 4th congressional district consisted of Baca, Bent, Cheyenne, Crowley, Elbert, Kiowa, Kit Carson, Larimer, Las Animas, Lincoln, Logan, Morgan, Otero, Phillips, Prowers, Sedgwick, Washington, Weld and Yuma counties, as well as portions of Adams and Arapahoe counties.

Following the 2000 U.S. census and associated realignment of Colorado congressional districts, the 4th congressional district consisted of Baca, Bent, Cheyenne, Crowley, Kiowa, Kit Carson, Larimer, Lincoln, Logan, Morgan, Phillips, Prowers, Sedgwick, Washington, Weld and Yuma counties, as well as portions of Boulder, and Otero counties.

On the other hand, the district takes in some of the most Republican counties in Colorado, such as Washington, Kit Carson, and Logan, where Democrats rarely exceed even 20 percent of the vote.

Historically, the district has been Republican-leaning, though Marilyn Musgrave won relatively narrow victories in 2004 and 2006 due to her Democratic opponents' strength in Fort Collins.

The current incumbent, Republican Lauren Boebert, was elected to the seat on November 5, 2024, having previously represented Colorado's 3rd Congressional District.