State Highway 133 (SH 133) is a 71.4 mi (114.9 km) long north–south byway connecting SH 92 to the south and SH 82 to the north, and travels through the towns of Hotchkiss, Somerset, Redstone, and Carbondale.

Highway 133 travels over a significant mountain pass on the northern end, called McClure Pass, which is 8,755 ft (2,669 m) above sea level.

The route's south terminus was adjusted back to Bardine in 1939, and a small gap at McClure pass was opened.

By 1954, a large section of the route was deleted, leaving only a four-mile (6 km) road near Carbondale.

The route was gradually expanded through the late 1950s and early 1960s.