For much of its length the road heads arrow straight due north across the eastern margin of the broad, flat, nearly featureless San Luis Valley between the Sangre de Christo Mountains in the east and the San Juan Mountains to the west.

The road eventually deviates from its due north heading as it approaches its northern endpoint at Great Sand Dunes National Park.

The first route to use the number 150 was established in the 1920s, when it connected SH 17 at Mosca to SH 69 at Gardner over Mosca Pass which is no longer maintained for automobile travel.

The route was deleted by 1954 and resurrected in 1960, when it connected Mosca with the Great Sand Dunes National Park.

[2] Media related to Colorado State Highway 150 at Wikimedia Commons