SH 266's western terminus is at U.S. Route 50 (US 50) and SH 71 in Rocky Ford, and the eastern terminus is at SH 109 near Cheraw.

SH 266 runs 11.5 miles (18.5 km), starting at a junction with US 50 in Rocky Ford.

The highway goes east, crosses the Arkansas River and ends at a junction with SH 109 near Cheraw.

The entire route is in Otero County.

Media related to Colorado State Highway 266 at Wikimedia Commons