SH 265 runs 3.6 miles (5.8 km), starting at a junction with I-70 in Denver.

The highway then turns northeast and runs along Brighton Boulevard, entering Commerce City.

The road continues northeast and ends at a junction with US 6 / US 85 in northern Commerce City.

The section south of York Street was part of the original routing of SH 224 until 1954, when it was rerouted and SH 265 was extended south onto this segment where it exists today.

[2] Media related to Colorado State Highway 265 at Wikimedia Commons