The western terminus is at Colorado Boulevard in Thornton, and the eastern terminus at SH 2 in Commerce City.

SH 44 travels 5.0 miles (8.0 km) along 104h Avenue.

It begins in Thornton at the intersection of Colorado Boulevard and runs due east.

It then intersects US 85 in Commerce City and then reaches its eastern terminus at the junction with SH 2.

Media related to Colorado State Highway 44 at Wikimedia Commons