The street continues northwest as Wildhorse Road in Pueblo West.

The route started as a rural highway in the 1960s, with the first section from I-25 northwest to SH 96 opening by 1966.

In theory, it would be useful to alleviate traffic jams in the area.

SH 45 is planned to eventually continue northeast from US 50 to I-25 around Milepost 103.

Media related to Colorado State Highway 45 at Wikimedia Commons