SH 61 begins at an at-grade intersection with US 34 at the south side of Otis.

It begins straight northward through town, in which roads are laid out in a grid-like pattern.

The road then exits the town, entering sparsely populated wilderness.

Near the Washington - Logan county line, the road abruptly turns westward and eastward again, crossing the boundary a few miles later.

[4] Media related to Colorado State Highway 61 at Wikimedia Commons