SH 63 begins in the south at a junction with U.S. Highway 36 at Anton and proceeds north through remote, sparsely populated land for roughly 29 miles (47 km) before reaching a junction with U.S. Highway 34 at Akron.

From there, the route continues north for a further 24 miles (39 km) to cross Interstate 76 at that highway's exit 115 and after roughly four more miles arrives at its northern terminus at U.S. Highway 6 in Atwood.

SH 63 was defined in the 1920s by the Colorado Department of Transportation, when it connected State Highway 96 in Haswell to Atwood at U.S. Highway 6.

The section was later deleted by 1954, leaving its current routing from Anton to Atwood.

[2] Media related to Colorado State Highway 63 at Wikimedia Commons