Columbine is a census-designated place (CDP) in and governed by Jefferson and Arapahoe counties in Colorado, United States.

Located primarily in Jefferson County, Columbine lies immediately south of Denver.

[6] Columbine grew rapidly during the Space Race years from 1958 to 1968 with the construction of the Martin Company missile facility in Waterton Canyon.

Columbine was the site of the Columbine High School massacre in 1999 perpetrated by Eric Harris and Dylan Klebold.Columbine is located on the eastern edge of Jefferson County with a small portion extending east into Arapahoe County.

The Denver city limits are 0.3 miles (0.48 km) north of the northern border of Columbine, and to the south the community extends as far as the Chatfield Reservoir dam.