Comanche Creek is an unincorporated community and a census-designated place (CDP) located in and governed by Arapahoe County, Colorado, United States.

The CDP is a part of the Denver–Aurora–Lakewood, CO Metropolitan Statistical Area.

The population of the Comanche Creek CDP was 442 at the United States Census 2020.

[3] The Strasburg post office (Zip code 80136) serves the area.

[1] The United States Census Bureau initially defined the Comanche Creek CDP for the United States Census 2010.