It first premiered in February 2003 in the new wave of Australian sketch comedy shows being launched across the free-to-air channels along with Big Bite and skitHOUSE.

When the series debuted, it rapidly gained the highest ratings of the three sketch comedies at that period of Australian television.

A recurring sketch features Emily Taheny as an unnamed woman who approaches other women at inappropriate and private moments such as going to the toilet, showering at a gym or giving birth to a baby.

Another recurring sketch features Katrina Retallick as a doctor who approaches her patients stating that "recent medical studies" show that song is the best way to convey possibly upsetting news.

The skit always begins with a comic strip story, explaining about an average man (who spoke in a general Australian accent) who made his own beer in his kitchen to have only had it explode, thus becoming "Blokeman".

Blokeman is looked upon as a normal hero, despite his obvious "bogan" qualities (ugg boots, mullet, beer belly, broad Australian accent).

A notable sketch with a father (Russell) who tucks his young son into bed every night, who usually asks him a question, but unbeknownst to himself, is slightly mature.

In 2005 two one-hour specials called "Comedy Inc: Takes out TV" were aired, the first during the series and then the week following the final episode before "The Late Shift".

This version was a success with both audiences and television critics, due to its slightly more risque content, as well as original new characters like "Blokeman" and "Matt and Bray".

The new series marked the departure of Ben Oxenbould and Gabriel Andrews from the show, and their replacement with the popular Australian comedian Scott Brennan and actor Simon Mallory.

Jim Schembri, notoriously tough television critic for the Melbourne newspaper The Age has described the show as "the hands-down funniest and smartest local laughfest on TV in 2006.

David McDonald received nominations for Best Direction in Television, and for Best Series (in his capacity as producer) at both the 2005 and 2006 "Australian Film Institute" Awards for his work on the show.