Four teams including some of the biggest names from films and television competed, and the show was hosted by Jennifer Winget.

Comedy Ka Maha Muqabala was launched on 19 March 2011 and was produced by Reliance BIG Entertainment.

The teams were captained by four Indian comedy celebrities—Arshad Warsi, Raveena Tandon, Shekhar Suman and Shreyas Talpade—who performed with a team of television celebrities, stand-up comedians and one comedy beginner in a variety of challenges.

Sucheta Khanna replaced Aashka Goradia from Raveena Ke Mohre in the fourth week.

Rajesh Kumar replaced Arhaan Behl from Shreyas Chi Mandli in week five.

In the eighth week, the challenge round was worth 50 points rather than 10, and Raveena Ke Mohre were eliminated.

The Tug of War (ToW) round was conducted twice in the tenth week, once for women and once for men.

Arshad Ke Punters then competed against Shreyas Chi Mandli and won a place in the finals.