Then between 1801 and the end in 1807 of British participation in the triangular trade in enslaved people, Commerce made four voyages as a slave ship and also spent some time in 1803 cruising as a privateer.

[2] Lloyd's List's ship arrival and departure data had her returning to England from Martinique in April 1801.

1st voyage transporting enslaved people (1801–1802): Captain John McLeeven acquired a letter of marque 16 May 1801.

[3] 2nd voyage transporting enslaved people (1802–1803): Captain McLeeven sailed from Liverpool on 19 May 1802, bound for West Africa.

[5] In February 1803 Lloyd's List reported that Commerce, M'Nevin, master, had arrived at St Kitts from Africa and had sold there.

[7] Lloyd's List's ship arrival and departure data noted that on 3 October Commerce, Towers, master, returned to Liverpool from a cruise.

3rd voyage transporting enslaved people (1804–1805): Captain James Woodstock acquired a letter of marque on 28 July 1804.

Commerce, Willey, master, left Grenada on 12 April, and arrived back at Liverpool on 17 June.

They left three men of her original complement on board, a lieutenant of the Royal Marines who had been sailing as a passenger, and two seamen.

[11] Lloyd's List reported in 1813 that Commerce, Blew, master, had sailed from Liverpool, via Cork, and arrived at Buenos Aires.

Then in November Lloyd's List reported that Commerce, Blew, master had struck on the Carnavon Bay as she was returning to Liverpool from Buenos Aires.